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Prostacyclin Receptor antibody (AA 101-200) (AbBy Fluor® 488)

PTGIR Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 488
Catalog No. ABIN1390492
  • Target See all Prostacyclin Receptor (PTGIR) Antibodies
    Prostacyclin Receptor (PTGIR)
    Binding Specificity
    • 14
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 101-200
    Reactivity
    • 47
    • 12
    • 4
    • 2
    • 2
    Human
    Host
    • 47
    • 3
    Rabbit
    Clonality
    • 47
    • 3
    Polyclonal
    Conjugate
    • 20
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Prostacyclin Receptor antibody is conjugated to AbBy Fluor® 488
    Application
    • 27
    • 21
    • 18
    • 12
    • 12
    • 7
    • 4
    • 3
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Prostaglandin I2 Receptor
    Isotype
    IgG
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    Discover our top product PTGIR Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Prostacyclin Receptor (PTGIR)
    Alternative Name
    Prostaglandin I2 Receptor (PTGIR Products)
    Synonyms
    IP antibody, PGI2 antibody, PRIPR antibody, prostaglandin I receptor (IP) antibody, prostaglandin I2 receptor antibody, Ptgir antibody, PTGIR antibody
    Background

    Synonyms: IP, PGI receptor, PGI2 receptor, PI2R_HUMAN, PRIPR, Prostacyclin receptor, Prostaglandin I2 receptor, Prostanoid IP receptor, PTGIR.

    Background: Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE2, PGF2?, PGI2, TXA2 and PGD2. These lipid mediators interact with specific members of G protein-coupled prostanoid receptors, designated EP, FP, IP, TP and DP, respectively. The IP Receptor binds prostacyclin, PGI2, the main pro-stanoid synthesized by vascular tissues.Upon binding to the IP Receptor, prostacyclin activates adenylate cyclase primarily through the Gas protein. The gene encoding the human IP Receptor is located on chromosome 19. It is expressed as a glycosylated and phosphorylated protein, which is abundantly expressed in vascular tissues such as aorta, lung, atrium and ventricle, as well as in kidney, thymus, spleen and neurons.

    Pathways
    cAMP Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling
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