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CREB3L3 antibody (AA 201-300) (FITC)

CREB3L3 Reactivity: Human WB, FACS, IF (p), IF (cc) Host: Rabbit Polyclonal FITC
Catalog No. ABIN1390100
  • Target See all CREB3L3 Antibodies
    CREB3L3 (cAMP Responsive Element Binding Protein 3-Like 3 (CREB3L3))
    Binding Specificity
    • 15
    • 1
    • 1
    • 1
    AA 201-300
    Reactivity
    • 25
    • 8
    • 8
    Human
    Host
    • 25
    Rabbit
    Clonality
    • 25
    Polyclonal
    Conjugate
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CREB3L3 antibody is conjugated to FITC
    Application
    • 18
    • 13
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CREB-H
    Isotype
    IgG
    Top Product
    Discover our top product CREB3L3 Primary Antibody
  • Application Notes
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    CREB3L3 (cAMP Responsive Element Binding Protein 3-Like 3 (CREB3L3))
    Alternative Name
    CREB-H/CREB3L3 (CREB3L3 Products)
    Synonyms
    CREB-H antibody, CREBH antibody, BC010786 antibody, D10Bur1e antibody, creb3l3a antibody, creb3l3b antibody, si:dkey-110c1.2 antibody, wu:fc88h05 antibody, zgc:112279 antibody, cAMP responsive element binding protein 3 like 3 antibody, cAMP responsive element binding protein 3-like 3 antibody, cAMP responsive element binding protein 3-like 3a antibody, CREB3L3 antibody, Creb3l3 antibody, creb3l3a antibody
    Background

    Synonyms: cAMP responsive element binding protein 3 like 3, cAMP responsive element-binding protein 3 like protein 3, CREB H, CREB/ATF family transcription factor, CREBH, Cyclic AMP responsive element binding protein 3 like protein 3, cAMP-responsive element-binding protein 3-like protein 3, HYST1481, MGC126553, MGC126557, Transcription factor CREB H, CR3L3_HUMAN.

    Background: CREB3L3 is a 461 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticulum (ER) and, in response to ER stress, is cleaved and translocated to the nucleus. Expressed exclusively in liver, CREB3L3 functions as a transcription factor that, during ER stress, is thought to activate genes that are involved in both the unfolded protein response and the acute phase response (APR). Additionally, CREB3L3 is underexpressed in hepatocellular carcinoma, suggesting a possible role as a tumor suppressor. CREB3L3 functions as a dimer and contains one leucine zipper domain, a KDEL-like sequence and a bZIP domain, through which it conveys its DNA binding ability. Three isoforms of CREB3L3 exist due to alternative splicing events.

    Pathways
    Thyroid Hormone Synthesis
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