AMIGO1 antibody (AA 131-230) (Biotin)

Catalog No. ABIN1389091

Product Details anti-AMIGO1 Antibody (Biotin)

Target: AMIGO1 (Adhesion Molecule with Ig-Like Domain 1 (AMIGO1))

Binding Specificity: AA 131-230

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AMIGO1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AMIGO1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for AMIGO1

Target: AMIGO1 (Adhesion Molecule with Ig-Like Domain 1 (AMIGO1))

Alternative Name: AMIGO1 (AMIGO1 Products)

Synonyms: A antibody, Amigo antibody, ali2 antibody, AMIGO antibody, AMIGO-1 antibody, adhesion molecule with Ig like domain 1 antibody, Amigo1 antibody, AMIGO1 antibody

Background:

Synonyms: Adhesion molecule with Ig like domain 1, ali2, Alivin 2, AMIGO 1, AMIGO, AMIGO protein, Amphoterin induced gene and ORF Amigo, Amphoterin induced gene and ORF, Amphoterin induced protein 1, KIAA1163, AMGO1_HUMAN.

Background: The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction.