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GAN antibody (AA 351-450) (AbBy Fluor® 488)

GAN Reactivity: Rat IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 488
Catalog No. ABIN1388824
  • Target See all GAN Antibodies
    GAN (Gigaxonin (GAN))
    Binding Specificity
    • 14
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 351-450
    Reactivity
    • 19
    • 14
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Rat
    Host
    • 24
    • 4
    Rabbit
    Clonality
    • 25
    • 3
    Polyclonal
    Conjugate
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GAN antibody is conjugated to AbBy Fluor® 488
    Application
    • 12
    • 12
    • 9
    • 9
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Rat
    Predicted Reactivity
    Human,Mouse,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Gigaxonin
    Isotype
    IgG
    Top Product
    Discover our top product GAN Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    GAN (Gigaxonin (GAN))
    Alternative Name
    Gigaxonin (GAN Products)
    Synonyms
    MGC81691 antibody, GAN antibody, A330045G18 antibody, gigaxonin antibody, GAN1 antibody, KLHL16 antibody, gigaxonin L homeolog antibody, gigaxonin antibody, giant axonal neuropathy antibody, gan.L antibody, gan antibody, GAN antibody, Gan antibody
    Background

    Synonyms: FLJ38059, GAN, GAN1, Kelch-like protein 16, giant axonal neuropathy, KLHL16, GAN_HUMAN.

    Background: Gigaxonin, also refered to as giant axonal neuropathy, GAN1, or KLHL16, controls protein degradation and is essential for neuronal function and survival. Gigaxonin is a member of the cytoskeletal BTB/kelch repeat family and influences cytoskeletal organization and dynamics, playing a large role in neurofilament architecture. The amino terminal BTB domain of gigaxonin binds to the ubiquitin-activating enzyme E1, while the carboxy-terminal kelch repeat domain interacts directly with the light chain of microtubule-associated protein 1B (MAP1B), and tags it for degredation. Overexpression of MAP1B may lead to neuronal cell death, whereas a reduction of MAP1B significantly improves the survival rate of neurons. Mutations in the Gigaxonin gene result in human giant axonal neuropathy (GAN), an autosomal recessive neurodegenerative disorder characterized by axonal degeneration caused by cytoskeletal abnormalities, including accumulated intermediate filaments.

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