Ferric-Chelate Reductase 1 Like (FRRS1L) antibody

Catalog No. ABIN1387966

Product Details

Target: Ferric-Chelate Reductase 1 Like (FRRS1L)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Brain protein CG6

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details

Target: Ferric-Chelate Reductase 1 Like (FRRS1L)

Alternative Name: Brain protein CG6 (FRRS1L Products)

Synonyms: C9orf4 antibody, CG-6 antibody, CG6 antibody, 6430704M03Rik antibody, ferric chelate reductase 1 like antibody, ferric-chelate reductase 1 like antibody, FRRS1L antibody, Frrs1l antibody

Background:

Synonyms: Brain protein CG 6, Brain protein CG-6, Brain protein CG6, C9orf4, CG 6, CG6, chromosome 9 open reading frame 4, CI004_HUMAN, Uncharacterized protein C9orf4.

Background: C9orf4 is a 344 amino acid single-pass membrane protein that is primarily expressed in adult and fetal brain and is weakly expressed in spinal cord, adult ovary and medulla. C9orf4 contains one DOMON domain, a predominantly _-sheet domain that is thought to aide in extracellular adhesion. The gene encoding C9orf4 maps to human chromosome 9, which consists of about 145 million bases and 4 % of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.