SYNM antibody (AA 501-650)

Catalog No. ABIN1387897

Product Details anti-SYNM Antibody

Target: SYNM (Synemin, Intermediate Filament Protein (SYNM))

Binding Specificity: AA 501-650

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYNM antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Desmuslin

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-SYNM antibody (ABIN1387897)

Bengoechea, Pittman, Tuck, True, Weihl: "Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D." in: Human molecular genetics, Vol. 24, Issue 23, pp. 6588-602, (2015) (PubMed).

Target Details for SYNM

Target: SYNM (Synemin, Intermediate Filament Protein (SYNM))

Alternative Name: Desmuslin (SYNM Products)

Synonyms: DMN antibody, dmn antibody, si:dkey-25f3.3 antibody, SYN antibody, 4930412K21Rik antibody, AI852401 antibody, Dmn antibody, E130104F11 antibody, Syn antibody, Synemin antibody, synemin antibody, synemin, intermediate filament protein antibody, SYNM antibody, synm antibody, Synm antibody

Background:

Synonyms: DMN, SYN, Synemin, Desmuslin, SYNM, KIAA0353

Background: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.

Gene ID: 23336

UniProt: O15061