BBS9 antibody (AA 244-320)

Catalog No. ABIN1387812

Product Details anti-BBS9 Antibody

Target: BBS9 (Bardet-Biedl Syndrome 9 (BBS9))

Binding Specificity: AA 244-320

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS9 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BBS9

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for BBS9

Target: BBS9 (Bardet-Biedl Syndrome 9 (BBS9))

Alternative Name: BBS9 (BBS9 Products)

Synonyms: b1 antibody, B1 antibody, C18 antibody, D1 antibody, PTHB1 antibody, RGD1308472 antibody, E130103I17Rik antibody, Bardet-Biedl syndrome 9 antibody, bardet-biedl syndrome 9 antibody, Bardet-Biedl syndrome 9 (human) antibody, BBS9 antibody, bbs9 antibody, Bbs9 antibody

Background:

Synonyms: B1, D1, C18, PTHB1, Protein PTHB1, Bardet-Biedl syndrome 9 protein, Parathyroid hormone-responsive B1 gene protein, BBS9

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.

Gene ID: 27241

UniProt: Q3SYG4

Pathways: Hedgehog Signaling