RND2 antibody (AA 1-80)

Catalog No. ABIN1387641

Product Details anti-RND2 Antibody

Target: RND2 (rho Family GTPase 2 (RND2))

Binding Specificity: AA 1-80

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RND2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RND2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for RND2

Target: RND2 (rho Family GTPase 2 (RND2))

Alternative Name: RND2/Rho7 (RND2 Products)

Synonyms: Rho antibody, arhn antibody, si:dz163l24.1 antibody, zgc:153204 antibody, ARHN antibody, RHO7 antibody, RhoN antibody, Arhn antibody, Rohn antibody, Rho family GTPase 2 antibody, RND2 antibody, rnd2 antibody, Rnd2 antibody

Background:

Synonyms: ARHN, Rho 7, Rho family GTPase 2, Rho N, Rho related GTP-binding protein RhoN, Rho-related GTP-binding protein Rho7, Rho-related GTP-binding protein RhoN, Rho7, RhoN, Rnd 2, Rnd2, RND2_HUMAN.

Background: The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50 % amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30 % homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine, A, aliphatic amino acid, X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.

Pathways: Regulation of Cell Size