TAL1 antibody

Catalog No. ABIN1387618

Product Details anti-TAL1 Antibody

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Tal1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-TAL1 antibody (ABIN1387618)

Niderla-Bieli?ska, Gula, Flaht-Zabost, Jankowska-Steifer, Czarnowska, Radomska-Le?niewska, Ciszek, Ratajska: "3-D reconstruction and multiple marker analysis of mouse proepicardial endothelial cell population." in: Microvascular research, Vol. 102, pp. 54-69, (2015) (PubMed).

Target Details for TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Alternative Name: Tal1 (TAL1 Products)

Synonyms: SCL/tal-1 antibody, Scl antibody, bHLHa17 antibody, tal-1 antibody, SCL antibody, TCL5 antibody, scl antibody, tcl5 antibody, SCL-alpha antibody, SCL-beta antibody, scl/tal1 antibody, zgc:85605 antibody, T cell acute lymphocytic leukemia 1 antibody, TAL bHLH transcription factor 1, erythroid differentiation factor antibody, T-cell acute lymphocytic leukemia 1 S homeolog antibody, T-cell acute lymphocytic leukemia 1 antibody, Tal1 antibody, TAL1 antibody, tal1.S antibody, tal1 antibody

Background:

Synonyms: bHLHa17, Class A basic helix-loop-helix protein 17, SCL antibody, Stem cell protein, T cell acute lymphocytic leukemia 1, T cell acute lymphocytic leukemia 1 protein, T cell leukemia/lymphoma 5 protein, T-cell acute lymphocytic leukemia protein 1, T-cell leukemia/lymphoma protein 5, Tal 1, Tal 1 product, TAL 1 protein, TAL-1, tal1, TAL1_HUMAN, TCL 5, TCL5.

Background: Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.

Pathways: Stem Cell Maintenance