PEN2 antibody (AA 6-80)

Catalog No. ABIN1387540

Product Details anti-PEN2 Antibody

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Binding Specificity: AA 6-80

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Belongs to the PEN-2 family

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PEN2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-PEN2 antibody (ABIN1387540)

Chu, Peng, Long, Wang, Luo, Sharma, He: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).

Target Details for PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Alternative Name: PEN2 (PSENEN Products)

Synonyms: MSTP064 antibody, PEN-2 antibody, PEN2 antibody, Psenen antibody, ACYPI006208 antibody, 1700023M09Rik antibody, Pen-2 antibody, RGD1312037 antibody, CG33198 antibody, Dmel\\CG33198 antibody, anon-AE003800.1 antibody, dPen-2 antibody, psenen antibody, pen-2 antibody, pen2 antibody, zgc:109727 antibody, presenilin enhancer gamma-secretase subunit antibody, presenilin enhancer 2 antibody, presenilin enhancer gamma secretase subunit antibody, Gamma-secretase subunit pen-2 antibody, presenilin enhancer antibody, presenilin enhancer gamma secretase subunit S homeolog antibody, PSENEN antibody, PEN2 antibody, Psenen antibody, pen-2 antibody, psenen.S antibody, psenen antibody

Background:

Synonyms: PEN2, PEN-2, MDS033, MSTP064, Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PSENEN

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.

Gene ID: 55851

UniProt: Q9NZ42

Pathways: Notch Signaling, Neurotrophin Signaling Pathway