THO Complex 2 antibody (AA 101-200)
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- Target See all THO Complex 2 (THOC2) Antibodies
- THO Complex 2 (THOC2)
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Binding Specificity
- AA 101-200
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This THO Complex 2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human THOC2
- Isotype
- IgG
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- THO Complex 2 (THOC2)
- Alternative Name
- THOC2 (THOC2 Products)
- Synonyms
- RGD1561623 antibody, THO antibody, Tho2 antibody, fb73e08 antibody, fd21d11 antibody, wu:fb73e08 antibody, wu:fd21d11 antibody, si:bz1o18.2 antibody, CXorf3 antibody, THO2 antibody, dJ506G2.1 antibody, hTREX120 antibody, 6330441O12Rik antibody, D130005M13Rik antibody, Gm1139 antibody, Gm1793 antibody, THO complex 2 antibody, Thoc2 antibody, THOC2 antibody, thoc2 antibody
- Background
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Synonyms: THO2, CXorf3, hTREX120, dJ506G2.1, THO complex subunit 2, THOC2
Background: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim.
- Gene ID
- 57187
- UniProt
- Q8NI27
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