TROVE2 antibody (AA 331-430)

Catalog No. ABIN1387451

Product Details anti-TROVE2 Antibody

Target: TROVE2 (TROVE Domain Family, Member 2 (TROVE2))

Binding Specificity: AA 331-430

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TROVE2 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TROVE-2/SSA2

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TROVE2

Target: TROVE2 (TROVE Domain Family, Member 2 (TROVE2))

Alternative Name: TROVE-2 (TROVE2 Products)

Synonyms: SSA2 antibody, TROVE2 antibody, ssa2 antibody, ssa2-A antibody, RO60 antibody, RORNP antibody, 1810007I17Rik antibody, A530054J02Rik antibody, AI646302 antibody, SS-A/Ro antibody, Ssa antibody, Ssa2 antibody, TROVE domain family member 2 antibody, TROVE domain family, member 2 antibody, TROVE domain family member 2 L homeolog antibody, TROVE2 antibody, trove2 antibody, trove2.L antibody, Trove2 antibody

Background:

Synonyms: TROVE2, 60 kDa ribonucleoprotein Ro, 60 kDa Ro protein, 60 kDa SS A/Ro ribonucleoprotein, 60 kDa SS-A/Ro ribonucleoprotein, Autoantigen Ro/SSA, 60-KD, bA101E13.2, Gastric cancer multi drug resistance protein, Ribonucleoprotein autoantigen SS A/Ro, RO 60, Ro 60 kDa autoantigen, RO60, RO60_HUMAN, RoRNP, Sjoegren syndrome antigen A2, Sjoegren syndrome type A antigen, Sjogren syndrome antigen A2 60kD ribonucleoprotein autoantigen SS A/Ro, Sjogren syndrome antigen A2 60 kDa ribonucleoprotein autoantigen SS A/Ro, Sjogren syndrome antigen A2, SS A, SS-A, SS-A/Ro, SSA 2, SSA, SSA2, TROVE 2, TROVE domain family member 2, TROVE2.

Background: Ro autoantigens are of clinical significance because directed against them are found in most patients with primary Sjqgren syndrome, subacute cutaneous lupus erythematosus (SLE), neonatal lupus erythematosus, ANA-negative lupus erythematosus, and systemic lupus erythematosus-like disease secondary to homozygous C2 or C4 complement deficiency (1). Ro/SSA is a ribonucleoprotein that binds to auto in 35 to 50 % of patients with SLE and in up to 97 % of patients with Sjqgren syndrome (2). The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules (2). Most anti-Ro/SSA-positive sera detect not only the main protein, but also a smaller Ro/SSA protein (2). The genes which encode the smaller and larger proteins map to human chromosomes 11p15.5 and 1q31, respectively (3?). La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with auto from patients with Sjren syndrome and SLE (6).