BBS1 antibody (AA 181-270)

Catalog No. ABIN1387440

Product Details anti-BBS1 Antibody

Target: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Binding Specificity: AA 181-270

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BBS1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for BBS1

Target: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Alternative Name: BBS1 (BBS1 Products)

Synonyms: im:7144669 antibody, bbs2l2 antibody, BBS1 antibody, DKFZp468B1612 antibody, BBS2L2 antibody, AI451249 antibody, D19Ertd609e antibody, Bardet-Biedl syndrome 1 antibody, bardet-biedl syndrome 1 antibody, Bardet-Biedl syndrome 1 (human) antibody, BBS1 antibody, bbs1 antibody, Bbs1 antibody

Background:

Synonyms: AI451249, Bardet-Biedl syndrome 1, Bardet-Biedl syndrome 1 homolog, Bardet-Biedl syndrome 1 protein, BBS1, BBS1_HUMAN, BBS2-like protein 2, D19Ertd609e.

Background: The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.

Pathways: Hedgehog Signaling