GDF6 antibody (AA 336-410)

Catalog No. ABIN1387414

Product Details anti-GDF6 Antibody

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Binding Specificity: AA 336-410

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDF6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GDF6

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for GDF6

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Alternative Name: GDF6 (GDF6 Products)

Synonyms: BMP13 antibody, CDMP2 antibody, KFM antibody, KFS antibody, KFS1 antibody, KFSL antibody, LCA17 antibody, MCOP4 antibody, MCOPCB6 antibody, SCDO4 antibody, SGM1 antibody, GDF16 antibody, gdf16 antibody, CDMP-2 antibody, gdf6 antibody, rdr antibody, sb:cb278 antibody, bmp13 antibody, cdmp2 antibody, gdf-6 antibody, kfs antibody, kfsl antibody, sgm1 antibody, growth differentiation factor 6 antibody, growth differentiation factor 6a antibody, growth differentiation factor 6 S homeolog antibody, GDF6 antibody, Gdf6 antibody, gdf6 antibody, gdf6a antibody, gdf6.S antibody

Background:

Synonyms: bmp 13, bmp13, bmp-13, Cartilage Derived Morphogenetic Protein 2, cdmp 2, CDMP2, gdf 6, GDF16 , Growth dferentiation factor 6, Growth/dferentiation factor 6, GDF6_HUMAN.

Background: Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1).