TSEN15 antibody
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- Target See all TSEN15 Antibodies
- TSEN15 (tRNA Splicing Endonuclease 15 Homolog (TSEN15))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TSEN15 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human C1orf19/SEN15
- Isotype
- IgG
- Top Product
- Discover our top product TSEN15 Primary Antibody
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- Application Notes
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- TSEN15 (tRNA Splicing Endonuclease 15 Homolog (TSEN15))
- Alternative Name
- C1orf19 (TSEN15 Products)
- Synonyms
- 5730449L18Rik antibody, AL023077 antibody, Sen15 antibody, C1orf19 antibody, sen15 antibody, tRNA splicing endonuclease subunit 15 antibody, Tsen15 antibody, TSEN15 antibody
- Background
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Synonyms: Chromosome 1 open reading frame 19, Chromosome 1 open reading frame 19, isoform CRA_c, HsSen15, sen15, SEN15 homolog, SEN15_HUMAN, tRNA intron endonuclease Sen15, tRNA splicing endonuclease 15 homolog S. cerevisiae, tRNA splicing endonuclease subunit Sen15, tRNA-intron endonuclease SEN15, tRNA-splicing endonuclease subunit SEN15, Tsen15.
Background: SEN15, also known as TSEN15 (tRNA-splicing endonuclease subunit Sen15) or C1orf19, is a nuclear protein that plays a role in tRNA splicing. Widely expressed with highest expression in testis and uterus, SEN15 is a non-catalytic subunit of the multi-protein tRNA-splicing endonuclease complex. The endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5? and 3? splice sites, thereby releasing introns and free tRNA molecules with 2',3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. As a subunit of the complex, SEN15 participates in protein expression and, ultimately, cell growth and division.
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