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FEZ1 antibody

FEZ1 Reactivity: Human, Rat, Mouse WB, IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1387129
  • Target See all FEZ1 Antibodies
    FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))
    Reactivity
    Human, Rat, Mouse
    Host
    • 25
    • 2
    • 1
    Rabbit
    Clonality
    • 28
    Polyclonal
    Conjugate
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FEZ1 antibody is un-conjugated
    Application
    • 23
    • 12
    • 6
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FEZ1
    Isotype
    IgG
    Top Product
    Discover our top product FEZ1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))
    Alternative Name
    FEZ1 (FEZ1 Products)
    Synonyms
    UNC-76 antibody, UNC76 antibody, wu:fj14c12 antibody, zgc:73258 antibody, fez1 antibody, xfez1 antibody, fasciculation and elongation protein zeta 1 antibody, fasciculation and elongation protein zeta 1 (zygin I) antibody, fasciculation and elongation protein zeta 1 L homeolog antibody, FEZ1 antibody, Fez1 antibody, fez1 antibody, fez1.L antibody
    Background

    Synonyms: Fasciculation and elongation protein zeta 1, Fasciculation and elongation protein zeta-1, Fez 1, Fez, Fez-like zinc finger protein, FEZ1, FEZ1_HUMAN, Fezl, Forebrain embryonic zinc-finger like protein, Zpf312, Zygin 1, Zygin I, Zygin-1, Zygin1, ZyginI.

    Background: Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.

    Gene ID
    9638
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