TMIGD1 antibody (AA 160-200)

Catalog No. ABIN1387070

Product Details anti-TMIGD1 Antibody

Target: TMIGD1 (Transmembrane and Immunoglobulin Domain Containing 1 (TMIGD1))

Binding Specificity: AA 160-200

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMIGD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TMIGD1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TMIGD1

Target: TMIGD1 (Transmembrane and Immunoglobulin Domain Containing 1 (TMIGD1))

Alternative Name: TMIGD1 (TMIGD1 Products)

Synonyms: RGD1307444 antibody, Tmigd antibody, TMIGD antibody, UNQ9372 antibody, 2010002A20Rik antibody, transmembrane and immunoglobulin domain containing 1 antibody, Tmigd1 antibody, TMIGD1 antibody

Background:

Synonyms: TMIGD, UNQ9372, Transmembrane and immunoglobulin domain-containing protein 1, TMIGD1, UNQ9372/PRO34164

Background: Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dub? syndrome and Canavan disease are also associated with chromosome 17.

Gene ID: 388364

UniProt: Q6UXZ0