CDX1 antibody

Catalog No. ABIN1386993

Product Details anti-CDX1 Antibody

Target: CDX1 (Caudal Type Homeobox 1 (CDX1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDX1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CDX1

Target: CDX1 (Caudal Type Homeobox 1 (CDX1))

Alternative Name: CDX1 (CDX1 Products)

Synonyms: Cdx antibody, Cdx-1 antibody, cdx-1 antibody, xcad2 antibody, xtcad2 antibody, CDX-A antibody, CDXA antibody, CHOX-CAD1 antibody, CHox-cad antibody, CDX1 antibody, xCAD2 antibody, zgc:165581 antibody, cdx2 antibody, caudal type homeobox 1 antibody, caudal type homeo box 1 antibody, caudal type homeobox 1 S homeolog antibody, caudal type homeobox 1 b antibody, caudal type homeobox 1a antibody, CDX1 antibody, Cdx1 antibody, cdx1 antibody, cdx1.S antibody, cdx1b antibody, cdx1a antibody

Background:

Synonyms: Caudal type homeo box transcription factor 1, Caudal type homeobox 1, Caudal type homeobox protein, Caudal type homeobox protein CDX1, Caudal type homeobox transcription factor 1, Caudal-type homeobox protein 1, CDX1, CDX1_HUMAN, Homeobox protein CDX 1, Homeobox protein CDX-1.

Background: The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila caudal? gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation. Cdx1 positively regulates its own expression. Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways. The human Cdx1 gene maps to chromosome 5q31-q33 and encodes a 265-amino acid protein.

Gene ID: 1044