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TRIM11 antibody

TRIM11 Reactivity: Human, Mouse, Rat WB, IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1386952
  • Target See all TRIM11 Antibodies
    TRIM11 (Tripartite Motif Containing 11 (TRIM11))
    Reactivity
    • 48
    • 19
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 46
    • 2
    Rabbit
    Clonality
    • 48
    Polyclonal
    Conjugate
    • 14
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TRIM11 antibody is un-conjugated
    Application
    • 37
    • 20
    • 18
    • 12
    • 5
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TRIM11/RNF92
    Isotype
    IgG
    Top Product
    Discover our top product TRIM11 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    TRIM11 (Tripartite Motif Containing 11 (TRIM11))
    Alternative Name
    RNF92 (TRIM11 Products)
    Synonyms
    BIA1 antibody, RNF92 antibody, TRIM11 antibody, tripartite motif containing 11 antibody, tripartite motif-containing 11 antibody, TRIM11 antibody, Trim11 antibody
    Background

    Synonyms: BIA 1, E3 ubiquitin protein ligase TRIM11, E3 ubiquitin-protein ligase TRIM11, Protein BIA1, RING finger protein 92, RNF 92, TRI11_HUMAN, Trim 11, TRIM11, Tripartite mot containing 11, tripartite mot protein 11, Tripartite mot-containing protein 11.

    Background: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

    Gene ID
    81559
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