HIP1R antibody

Catalog No. ABIN1386914

Product Details anti-HIP1R Antibody

Target: HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIP1R antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HIP1R/HIP12/HIP3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for HIP1R

Target: HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))

Alternative Name: HIP12 (HIP1R Products)

Synonyms: HIP12 antibody, HIP3 antibody, ILWEQ antibody, AA410023 antibody, mKIAA0655 antibody, HIP1R antibody, hip1r antibody, hip3 antibody, hip12 antibody, ilweq antibody, DKFZp469N2015 antibody, hip1 antibody, MGC78813 antibody, huntingtin interacting protein 1 related antibody, huntingtin interacting protein 1 related b antibody, huntingtin interacting protein 1 related L homeolog antibody, HIP1R antibody, Hip1r antibody, hip1rb antibody, hip1r antibody, hip1r.L antibody

Background:

Synonyms: Hip1 related, HIP12, HIP3, Huntingtin Interacting Protein 1 Related, HIP1R, Huntingtin interacting protein 12, HIP1R_HUMAN.

Background: Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. HIP1, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin. The HIP1 gene locates to the human chromosome 7q11.23. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking, the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.

Gene ID: 9026