DR1 antibody

Catalog No. ABIN1386906

Product Details anti-DR1 Antibody

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DR1 protein

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for DR1

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Alternative Name: DR1 Protein (DR1 Products)

Synonyms: BG:DS00929.3 antibody, CG4185 antibody, Dmel\\CG4185 antibody, Dr1 antibody, NC2 beta antibody, Nc2b antibody, dDr1 antibody, dNC2 antibody, wu:fj15f04 antibody, zgc:152914 antibody, 1700121L09Rik antibody, Dr1l antibody, NC2 antibody, NC2beta antibody, NC2-BETA antibody, Negative Cofactor 2beta antibody, TATA-BINDING PROTEIN-ASSOCIATED PHOSPHOPROTEIN antibody, TATA-binding protein-associated phosphoprotein antibody, putative tata-binding protein-associated phosphoprotein antibody, down-regulator of transcription 1 antibody, down-regulator of transcription 1, TBP-binding (negative cofactor 2) antibody, NC2beta antibody, ECU11_0730 antibody, EDI_229030 antibody, PTRG_08168 antibody, Smp_160150 antibody, EBI_26279 antibody, EBI_23074 antibody, VDBG_02216 antibody, dr1 antibody, Dr1 antibody, DR1 antibody

Background:

Synonyms: Dr1 protein; NC2; Negative cofactor 2 beta; Down regulator of transcription 1; Down regulator of transcription 1 TBP binding; Down-regulator of transcription 1; DR 1; Dr1; NC 2; NC2 beta; NC2-beta; NC2B_HUMAN; Negative co factor 2; Negative cofactor 2; Negative cofactor 2-beta; Protein Dr1; TATA binding protein associated phosphoprotein; TATA-binding protein-associated phosphoprotein.

Background: DR1, also known as NC2 (negative cofactor 2 subunit ), is a TFIID (TATA box-binding protein)-associated protein. DR1 localizes to the nucleus and contains an N-terminal histone fold motif, a TFIID-binding domain and an alanine and glutamine rich region. Via its histone fold motif, DR1 forms a heterodimer with NC2å (DRAP1) to comprise the conserved eukaryotic complex, NC2 (negative cofactor 2). The NC2 complex can both positively and negatively regulate transcription by RNA Pol II. More specifically, NC2 acts as a repressor of TATA-dependent transcription and acts as an activator for DPE-dependent transcription. NC2 represses RNA Pol II transcription by binding to TFIID and inhibiting association of the transcription factors TFIIA and TFIIB. NC2 activity is regulated by phosphorylation. Both subunits, NC2å and DR1, are phosphorylated in vivo.

Gene ID: 10589