UGCG antibody (AA 31-98)

Catalog No. ABIN1386872

Product Details anti-UGCG Antibody

Target: UGCG (UDP-Glucose Ceramide Glucosyltransferase (UGCG))

Binding Specificity: AA 31-98

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UGCG antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UGCG

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for UGCG

Target: UGCG (UDP-Glucose Ceramide Glucosyltransferase (UGCG))

Alternative Name: UGCG (UGCG Products)

Synonyms: GCS antibody, GLCT1 antibody, XLCGT antibody, gcs antibody, glct1 antibody, ugcga antibody, xlcgt antibody, cb539 antibody, sb:cb539 antibody, zgc:112506 antibody, ugcg antibody, ugcgb antibody, AU043821 antibody, C80537 antibody, Epcs21 antibody, GlcT-1 antibody, Ugcgl antibody, UDP-glucose ceramide glucosyltransferase antibody, UDP-glucose ceramide glucosyltransferase L homeolog antibody, UDP-glucose ceramide glucosyltransferase S homeolog antibody, UGCG antibody, ugcg.L antibody, Ugcg antibody, ugcg antibody, ugcg.S antibody

Background:

Synonyms: CEGT_HUMAN, Ceramide glucosyltransferase, GCS, GLCT 1, GLCT-1, GLCT1, Glucosylceramide synthase, UDP glucose ceramide glucosyltransferase, UDP glucose N acylsphingosine D glucosyltransferase, UDP-glucose ceramide glucosyltransferase, UDP-glucose:N-acylsphingosine D-glucosyltransferase, Ugcg.

Background: Glucosylceramide synthase (GCS), also designated ceramide glucosyltransferase, belongs to the glycosyltransferase 2 family. It is a widely expressed integral membrane protein encoded by UGCG. The enzyme can be found in the plasma membrane of all eukaryotic cells, and a significant concentration of glucosylceramide synthase activity has been reported in the Golgi complex. Glucosylceramide synthase catalyzes the first glycosylation step in glycosphingolipid biosynthesis and functions as a glucosyltransferase and flippase in the transfer of glucose to ceramide. Glucosylceramide synthase operates in cell recognition, cell proliferation and differentiation, immune recognition and signal transduction. The regulation of ceramide levels through glucosylceramide synthase has been associated with the induction of apoptosis and notable research implicates this relationship with drug-induced apoptosis in a variety of cell types.