FBXL12 antibody (AA 171-270)

Catalog No. ABIN1386844

Product Details anti-FBXL12 Antibody

Target: FBXL12 (F-Box and Leucine-Rich Repeat Protein 12 (FBXL12))

Binding Specificity: AA 171-270

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FbxL12

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FBXL12

Target: FBXL12 (F-Box and Leucine-Rich Repeat Protein 12 (FBXL12))

Alternative Name: FbxL12 (FBXL12 Products)

Synonyms: Fbl12 antibody, FBXL12 antibody, fbl12 antibody, 3110048D16Rik antibody, F-box and leucine rich repeat protein 12 antibody, F-box and leucine-rich repeat protein 12 antibody, RNI-like superfamily protein antibody, FBXL12 antibody, Fbxl12 antibody, fbxl12 antibody, AT3G07550 antibody

Background:

Synonyms: F box and leucine rich repeat protein 12, F box protein FBL12, F box/LRR repeat protein 12, FBXL 12, FLJ20188, FXL12_HUMAN.

Background: F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚,B-å, and -catenin, for proteasomal degradation. FBL12 (F-box and leucine-rich repeat protein 12), also designated FBXL12, is a 326 amino acid protein that contains one F-box domain, five LRR (leucine-rich) repeats and exists as two alternatively spliced isoforms. FBL12 interacts with both Skp1 and CUL-1, and is encoded by a gene that maps to human chromosome 19p13.2.

Gene ID: 54850

Pathways: SARS-CoV-2 Protein Interactome