SESN1 antibody (AA 401-492)

Catalog No. ABIN1386803

Product Details anti-SESN1 Antibody

Target: SESN1 (Sestrin 1 (SESN1))

Binding Specificity: AA 401-492

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SESN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SESN1/PA26

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SESN1

Target: SESN1 (Sestrin 1 (SESN1))

Alternative Name: PA26 (SESN1 Products)

Synonyms: zgc:91970 antibody, sestrin-1 antibody, SESN1 antibody, XPA26 antibody, pa26 antibody, sest1 antibody, PA26 antibody, SEST1 antibody, 1110002G11Rik antibody, AU044290 antibody, Pa26 antibody, Sest1 antibody, sesn1-A antibody, sestrin 1 antibody, sestrin 1 L homeolog antibody, SESN1 antibody, sesn1 antibody, Sesn1 antibody, sesn1.L antibody

Background:

Synonyms: p53 regulated PA26 nuclear protein, p53 regulated protein PA26, p53-regulated protein PA26, PA26, sesn1, SESN1_HUMAN, SEST1, sestrin 1, Sestrin-1.

Background: Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and the mitotic inhibitory protein p21. GADD 45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase, and it apparently acts in concert with GADD 153 in inducing growth arrest. A related DNA-damage inducible gene, GADD 34 synergizes with GADD 45 or GADD 153 in suppressing cell growth. PEG-3 (progression elevated gene-3) shares significant homology with GADD 34 and is inducible by DNA damage. An additional GADD related gene, PA26, is a possible target of p53. Three isoforms of PA26 have been identified as PA26-T1, PA26-T2 and PA26-T3.

Gene ID: 27244