Complement Factor B antibody (AA 301-400)

Catalog No. ABIN1386781

Product Details anti-Complement Factor B Antibody

Target: Complement Factor B (CFB)

Binding Specificity: AA 301-400

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Complement factor-B Bb fragment

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Complement Factor B

Target: Complement Factor B (CFB)

Alternative Name: Factor B (CFB Products)

Synonyms: AHUS4 antibody, BF antibody, BFD antibody, CFAB antibody, FB antibody, FBI12 antibody, GBG antibody, H2-Bf antibody, PBF2 antibody, bf antibody, Bf-1 antibody, Brre-Bf antibody, zgc:114032 antibody, Bf antibody, Sp152 antibody, bfb-A antibody, Bf B antibody, LOC397725 antibody, bf/c2 antibody, CFB antibody, AI195813 antibody, AI255840 antibody, B antibody, C2 antibody, Fb antibody, Da1-24 antibody, complement factor B antibody, complement factor B S homeolog antibody, complement factor B L homeolog antibody, CFB antibody, cfb antibody, bf antibody, cfb.S antibody, cfb.L antibody, bf/c2 antibody, LOC100555981 antibody, Cfb antibody

Background:

Synonyms: BF, FB, BFD, GBG, CFAB, CFBD, PBF2, AHUS4, FBI12, H2-Bf, ARMD14, Complement factor B, C3/C5 convertase, Glycine-rich beta glycoprotein, Properdin factor B, CFB

Background: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Gene ID: 629

UniProt: P00751

Pathways: Complement System, Proton Transport, Ribonucleoside Biosynthetic Process