PNCK antibody (AA 31-160)

Catalog No. ABIN1386701

Product Details anti-PNCK Antibody

Target: PNCK (Pregnancy Up-Regulated Non-Ubiquitously Expressed CaM Kinase (PNCK))

Binding Specificity: AA 31-160

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNCK antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PNCK

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PNCK

Target: PNCK (Pregnancy Up-Regulated Non-Ubiquitously Expressed CaM Kinase (PNCK))

Alternative Name: PNCK (PNCK Products)

Synonyms: BSTK3 antibody, CaMK1b antibody, Bstk3 antibody, CaMKIbeta2 antibody, CaMKlb2 antibody, Camk1b antibody, Punc antibody, caMKlb1 antibody, pregnancy up-regulated nonubiquitous CaM kinase antibody, pregnancy upregulated non-ubiquitously expressed CaM kinase antibody, PNCK antibody, Pnck antibody

Background:

Synonyms: Calcium/calmodulin dependent protein kinase type 1B, Calcium/calmodulin-dependent protein kinase type 1B, CaM KI beta, CaM kinase I beta, CaM kinase IB, CaM-KI beta, CaMK1b, CaMKI beta, CaMKI-beta, EC 2.7.11.17, KCC1B_HUMAN, MGC45419, PNCK, Pregnancy up regulated non ubiquitously expressed CaM kinase, Pregnancy up-regulated non-ubiquitously-expressed CaM kinase.

Background: The Ca2+/calmodulin-dependent protein kinases (CaMKs) comprise a structurally related subfamily of serine/threonine kinases. CaMKI Beta (Ca2+/calmodulin-dependent protein kinase type 1B), also known as PNCK (pregnancy up-regulated non-ubiquitously expressed CaM kinase) or BSTK3, is a 343 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one protein kinase domain. Existing as multiple alternatively spliced isoforms, CaMKI Beta functions to catalyze the ATP-dependent phosphorylation of CaMKI, an event that activates CaMKI activity and may be important for Ca2+-triggered signaling cascades within the cell. The gene encoding CaMKI Beta maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes.