Serotonin Receptor 5A antibody (AA 1-110)

Catalog No. ABIN1386672

Product Details anti-Serotonin Receptor 5A Antibody

Target: Serotonin Receptor 5A (HTR5A)

Binding Specificity: AA 1-110

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 5A antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human 5HT5A receptor/SR-5A

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Serotonin Receptor 5A antibody (ABIN1386672)

García-Pedraza, Hernández-Abreu, Morán, Carretero, García-Domingo, Villalón: "Role of peripheral 5-HT5A receptors in 5-HT-induced cardiac sympatho-inhibition in type 1 diabetic rats." in: Scientific reports, Vol. 10, Issue 1, pp. 19358, (2021) (PubMed).

Target Details for Serotonin Receptor 5A

Target: Serotonin Receptor 5A (HTR5A)

Alternative Name: 5HT5A receptor/SR-5A (HTR5A Products)

Synonyms: HTR5A antibody, si:dkey-265a7.5 antibody, Htr5 antibody, 5-HT5A antibody, 5HT5A antibody, MR22 antibody, 5-hydroxytryptamine receptor 5A antibody, 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a antibody, 5-hydroxytryptamine (serotonin) receptor 5A antibody, HTR5A antibody, htr5aa antibody, Htr5a antibody

Background:

Synonyms: HTR5A, 5 HT 5A, 5 hydroxytryptamine 5A receptor, 5-HT-5, 5-HT-5A, 5-HT5A, 5-hydroxytryptamine receptor 5A, 5HT5A, 5HT5A_HUMAN, HTR5A, Serotonin receptor 5A.

Background: SR-5B, also designated 5-hydroxytryptamine (serotonin) receptor 5B (5-HT5B) and G protein-coupled receptor 134 (GPR134) is a receptor for the monoamine ligand serotonin (5-hydroxytryptamine, 5-HT). Serotonin is a neurotransmitter derived from serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin actions are mediated by receptors that influence the biochemistry of depression, anxiety, sexuality and appetite. Rat SR-5B is present in serotonergic neurons in dorsal raphe (DR) and central superior nucleus (CS, median raphe nucleus). DR cell bodies showing SR-5B mRNA expression are abundant in the medial portions of the nucleus. CS coexpression of SR-5B receptor mRNA with serotonin transporter mRNA is high in the intermediate portions of the nucleus. Serotonin receptors include SR-17 (5HT17). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F. Subtypes within the SR-2 group include SR-2A, -2B and -2C. Subtypes within the SR-5 group include SR-5A and -5B. SR receptors can couple to G proteins that act on either adenylate cyclase or phospholipase C (PLC). The SR-3 class of receptors are ion channels.32234.

Pathways: JAK-STAT Signaling