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TIMM8A/DDP antibody (AA 31-97)

TIMM8A Reactivity: Human ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1386581
  • Target See all TIMM8A/DDP (TIMM8A) Antibodies
    TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))
    Binding Specificity
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    AA 31-97
    Reactivity
    • 33
    • 10
    • 9
    • 1
    • 1
    Human
    Host
    • 28
    • 5
    Rabbit
    Clonality
    • 30
    • 3
    Polyclonal
    Conjugate
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TIMM8A/DDP antibody is un-conjugated
    Application
    • 12
    • 12
    • 9
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Predicted Reactivity
    Human,Mouse,Rat,Cow,Sheep,Pig
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TIMM8A
    Isotype
    IgG
    Top Product
    Discover our top product TIMM8A Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))
    Alternative Name
    TIMM8A (TIMM8A Products)
    Synonyms
    TIMM8A antibody, ddp antibody, tim8a antibody, timm8a antibody, DDP antibody, DDP1 antibody, DFN1 antibody, MTS antibody, TIM8 antibody, im:6896085 antibody, zgc:100916 antibody, Ddp1 antibody, Timm8a antibody, DXHXS1274E antibody, Fci-12 antibody, Tim8a antibody, translocase of inner mitochondrial membrane 8 homolog A (yeast) antibody, translocase of inner mitochondrial membrane 8A antibody, translocase of inner mitochondrial membrane 8 homolog A1 (yeast) antibody, translocase of inner mitochondrial membrane 8A1 antibody, TIMM8A antibody, timm8a antibody, Timm8a1 antibody
    Background

    Synonyms: DDP 1, DDP, DDP1, Deafness dystonia protein 1, Deafness/dystonia peptide, DFN 1, DFN1, MGC12262, Mitochondrial import inner membrane translocase subunit Tim8 A, MTS, TIM 8A, TIM8A, TIMM 8A, Translocase of inner mitochondrial membrane 8 homolog A, X linked deafness dystonia protein, TIM8A_HUMAN.

    Background: The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1). The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1,2). Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity (1). Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health (3,4). Tim8A and Tim8B, which map to human chromosomes Xq22.1 and 11q23.1-q23.2, respectively, are conserved proteins of the mitochondrial intermembrane space, which are organized in hetero-oligomeric complex with Tim13 (5,6,7). Tim8A is highly expressed in fetal and adult brain (5). Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, thought to be caused by a defective mitochondrial protein transport system (5,8).

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