ABLIM1 antibody (AA 681-778)

Catalog No. ABIN1386547

Product Details anti-ABLIM1 Antibody

Target: ABLIM1 (Actin Binding LIM Protein 1 (ABLIM1))

Binding Specificity: AA 681-778

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABLIM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ABLIM1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ABLIM1

Target: ABLIM1 (Actin Binding LIM Protein 1 (ABLIM1))

Alternative Name: ABLIM1 (ABLIM1 Products)

Synonyms: ABLIM1 antibody, 2210411C18Rik antibody, 2610209L21Rik antibody, 4833406P10Rik antibody, 9330196J19Rik antibody, AV079770 antibody, AW060987 antibody, AW215784 antibody, Limab1 antibody, abLIM-L antibody, abLIM-M antibody, abLIM-S antibody, mKIAA0059 antibody, ablim1 antibody, zgc:172321 antibody, RGD1565768 antibody, ABLIM antibody, LIMAB1 antibody, LIMATIN antibody, abLIM-1 antibody, si:dkeyp-84e12.1 antibody, zgc:112954 antibody, actin binding LIM protein 1 antibody, actin-binding LIM protein 1 antibody, actin binding LIM protein 1a antibody, actin binding LIM protein 1b antibody, ABLIM1 antibody, Ablim1 antibody, ablim1a antibody, ablim1b antibody

Background:

Synonyms: ABLIM 1, ABLIM, abLIM-1, ABLIM-L, ABLIM-M, ABLIM-S, ABLIM1, ABLM1_HUMAN, Actin binding double zinc finger protein, Actin binding LIM protein 1, Actin binding LIM protein family member 1, Actin-binding double zinc finger protein, Actin-binding double zinc finger protein, Actin-binding LIM protein 1, Actin-binding LIM protein family member 1, DKFZp781D0148, FLJ14564, KIAA0059, LIM actin binding protein 1, LIMAB 1, LIMAB1, Limatin, RGD1565768, RP11-317F20.1.

Background: The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription.

Gene ID: 3983