Synaptojanin 1 antibody (AA 481-580)

Catalog No. ABIN1386543

Product Details anti-Synaptojanin 1 Antibody

Target: Synaptojanin 1 (SYNJ1)

Binding Specificity: AA 481-580

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Synaptojanin 1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Synaptojanin/INPP5G

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Synaptojanin 1

Target: Synaptojanin 1 (SYNJ1)

Alternative Name: Synaptojanin 1 (SYNJ1 Products)

Synonyms: CG6562 antibody, Dmel\\CG6562 antibody, IPP antibody, Synj antibody, fb02f11 antibody, fi15a11 antibody, nrc antibody, wu:fb02f11 antibody, wu:fi15a11 antibody, SYNJ1 antibody, INPP5G antibody, A930006D20Rik antibody, AA675315 antibody, mKIAA0910 antibody, Synaptojanin antibody, synaptojanin 1 antibody, Synj antibody, synj1 antibody, SYNJ1 antibody, Synj1 antibody

Background:

Synonyms: 5-trisphosphate 5-phosphatase 1, Inositol 5' phosphatase, INPP 5G, INPP5G, KIAA0910, Polyphosphoinositide phosphatase, Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 1, Synaptic inositol 145 trisphosphate 5 phosphatase 1, Synaptic inositol-1 antibody Synaptic inositol-145-trisphosphate 5-phosphatase 1, Synaptojanin 1, Synaptojanin 1 polyphosphoinositide phosphatase, Synaptojanin-1, Synaptojanin1, Synj 1, Synj1, SYNJ1_HUMAN.

Background: The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. Synaptojanins are characterized by an N-terminal SAC1-like sequence, a central 5-phosphate domain, and a unique C-terminal sequence and have been shown to use phosphatidylinositol 4,5-bisphosphate as a substrate. Synaptojanins exist as two isoforms, synaptojanin 1 and 2, which differ in the C-terminal domain, and each isoform has multiple variants produced by alternative splicing. Synaptojanin 1 is expressed as two major forms: the shorter is found in brain while the longer is expressed in peripheral tissues. Eight splice variants of synaptojanin 2 have been detected, including a brain specific isoform. Synaptojanins are thought to participate in the endocytosis of synaptic vesicles and the regulation of the actin cytoskeleton.

Gene ID: 8867

Pathways: Inositol Metabolic Process, Synaptic Vesicle Exocytosis