HSC70 Interacting Protein HIP antibody (AA 181-280)

Catalog No. ABIN1386487

Product Details anti-HSC70 Interacting Protein HIP Antibody

Target: HSC70 Interacting Protein HIP (ST13) (Suppression of Tumorigenicity 13 (ST13))

Binding Specificity: AA 181-280

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSC70 Interacting Protein HIP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HSPABP

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for HSC70 Interacting Protein HIP

Target: HSC70 Interacting Protein HIP (ST13) (Suppression of Tumorigenicity 13 (ST13))

Alternative Name: ST13 (ST13 Products)

Synonyms: CG32789 antibody, Dmel\\CG32789 antibody, anon-EST:fe1A9 antibody, 1110007I03Rik antibody, 3110002K08Rik antibody, AW555194 antibody, HIP antibody, HOP antibody, HSPABP antibody, HSPABP1 antibody, PRO0786 antibody, SNC6 antibody, p48 antibody, AAG2 antibody, FAM10A1 antibody, FAM10A4 antibody, P48 antibody, Hsc/Hsp70-interacting protein antibody, suppression of tumorigenicity 13 antibody, ST13, Hsp70 interacting protein antibody, suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) antibody, HIP antibody, St13 antibody, ST13 antibody

Background:

Synonyms: AAG 2, AAG2, Aging associated protein 2, F10A1_HUMAN, FAM10A1, FAM10A4, FLJ27260, Heat shock 70kD protein binding protein, HIP, HOP, Hsc70 interacting protein, Hsc70-interacting protein, Hsp70 interacting protein, HSPABP 1, HSPABP, HSPABP1, MGC129952, OTTHUMP00000028873, P48 antibody PRO0786, Progesterone receptor associated p48 protein, Progesterone receptor-associated p48 protein, Protein FAM10A1, Putative tumor suppressor ST13, Renal carcinoma antigen NY REN 33, Renal carcinoma antigen NY-REN-33, SNC 6, SNC6, ST 13, ST13, Suppression of tumorigenicity 13, Suppression of tumorigenicity 13 colon carcinoma, Suppression of tumorigenicity 13 protein, Suppression of tumorigenicity protein 13.

Background: Hip (HSP70-interacting protein), also known as ST13 (suppression of tumorigenicity protein 13), is one of several co-chaperones that regulate activities of the HSP70 chaperone family (1,2). The homo-oligomeric protein Hip cooperates with HSP70 in protein folding by stabilizing the ADP-bound state of HSP70. Hip directly binds to the ATPase domain of HSP70 when it is converted to the ADP-bound state by proteins of the HSP40 family (3). By collaborating with other positive co-factors such as HSP40 and Hop, or competing with negative co-factors such as Bag1, Hip may facilitate the chaperone function of HSP70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and various regulators of proliferation or apoptosis (4-8).

Gene ID: 6767

UniProt: P50502