XPO5 antibody (AA 221-320)

Catalog No. ABIN1386464

Product Details anti-XPO5 Antibody

Target: XPO5 (Exportin 5 (XPO5))

Binding Specificity: AA 221-320

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPO5 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Exportin 5

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for XPO5

Target: XPO5 (Exportin 5 (XPO5))

Alternative Name: Exportin 5 (XPO5 Products)

Synonyms: exp5 antibody, CG12234 antibody, Dmel\\CG12234 antibody, Exp-5 antibody, Exp5 antibody, RanBP21 antibody, dmExp5 antibody, 2410004H11Rik antibody, 2700038C24Rik antibody, AI648907 antibody, AW549301 antibody, RanBp21 antibody, mKIAA1291 antibody, exportin-5 antibody, ranbp21 antibody, DDBDRAFT_0185980 antibody, DDBDRAFT_0237583 antibody, DDB_0185980 antibody, DDB_0237583 antibody, XPO5 antibody, exportin 5 antibody, CG12234 gene product from transcript CG12234-RB antibody, armadillo-like helical domain-containing protein antibody, XPO5 antibody, Ranbp21 antibody, Xpo5 antibody, xpo5 antibody

Background:

Synonyms: Exp 5, Exp5, Exportin 5, Exportin-5, Exportin5, FLJ14239, FLJ32057, FLJ45606, KIAA1291, Ran binding protein 21, Ran-binding protein 21, Ranbp 21, Ranbp21, Xpo 5, xpo5, XPO5_HUMAN.

Background: Exportin 5 (XPO5) is a member of the importin _ family of proteins and functions in tRNA export in a sequence dependent fashion. More recently, it has been shown to export pre-miRNA by a RanGTPase-driven process from the nucleus to the cytoplasm, where pre-miRNA processing occurs to produce mature miRNAs. Study of the miRNA biosynthesis pathway is essential in understanding the process of oncogenesis as global downregulation of miRNAs and the resulting alterations in the expression of tumor suppressor and oncogenic proteins is a common phenotype of cancers cells . Research studies have shown disruption of exportin 5 functions in many types of cancers including breast and lung, where pre-miRNA accumulates in the nucleus and miRNA maturation is impaired.

Pathways: Regulatory RNA Pathways, Protein targeting to Nucleus