ADRA2C antibody (AA 21-120)

Catalog No. ABIN1386323

Product Details anti-ADRA2C Antibody

Target: ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))

Binding Specificity: AA 21-120

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA2C antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ADRA2C/alpha 2C Adrenergic Receptor

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ADRA2C

Target: ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))

Alternative Name: ADRA2C/alpha 2C Adrenergic Receptor (ADRA2C Products)

Synonyms: ADRA2L2 antibody, ADRA2RL2 antibody, ADRARL2 antibody, ALPHA2CAR antibody, Adra-2c antibody, [a]2C antibody, alpha2-C4 antibody, alpha2C antibody, zgc:194523 antibody, zgc:194541 antibody, adra2c antibody, ADRA2B antibody, ADRA2C antibody, adrenoceptor alpha 2C antibody, adrenergic receptor, alpha 2c antibody, ADRA2C antibody, Adra2c antibody, adra2c antibody

Background:

Synonyms: Adra 2c, Adra 2c, ADRA2C, ADRA2C, ADRA2L2, ADRA2L2, ADRA2RL2, ADRA2RL2, ADRARL2, ADRARL2, Adrenergic alpha 2C receptor, Adrenoceptor alpha 2C, Alpha 2C adrenergic receptor, Alpha 2C adrenergic receptor subtype C4, Alpha 2C adrenoceptor, Alpha 2C adrenoreceptor, Alpha 2CAR, alpha2 AR C4, alpha2 AR C4, alpha2 C4, alpha2 C4, alpha2C, alpha2C, ALPHA2CAR, alpha2cii-adrenergic receptor, Subtype alpha2 C4, Subtype alpha2 C4, ADA2C_HUMAN.

Background: alpha2C-adrenergic receptors (alpha2C-AR) regulate neurotransmitter release from sympathetic nerves in the heart, and from adrenergic neurons in the central nervous system. alpha2C-AR can influence Parkinson?s disease, panic disorders, and Huntington disease (HD) progression. A genetic variant in the alpha2C-AR coding region (Del322-325) renders the receptor partially uncoupled from Gi, and is a contributing risk factor for heart failure. alpha2C-AR transcripts are present in rat muscle, heart, pancreas, and kidney.

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process