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Myosin VI antibody (AA 1101-1294)

MYO6 Reactivity: Mouse, Rat ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1386322
  • Target See all Myosin VI (MYO6) Antibodies
    Myosin VI (MYO6)
    Binding Specificity
    • 14
    • 8
    • 8
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    AA 1101-1294
    Reactivity
    • 30
    • 25
    • 25
    • 1
    • 1
    Mouse, Rat
    Host
    • 43
    • 1
    Rabbit
    Clonality
    • 43
    • 1
    Polyclonal
    Conjugate
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Myosin VI antibody is un-conjugated
    Application
    • 23
    • 19
    • 17
    • 13
    • 12
    • 12
    • 7
    • 5
    • 2
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Mouse, Rat
    Predicted Reactivity
    Human,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Myosin VI
    Isotype
    IgG
    Top Product
    Discover our top product MYO6 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    Myosin VI (MYO6)
    Alternative Name
    MYO6/Myosin VI (MYO6 Products)
    Synonyms
    95F antibody, 95F MHC antibody, CG5695 antibody, Dm 95F antibody, Dm95F antibody, Dmel\\CG5695 antibody, Dro95F antibody, JAG antibody, Jaguar antibody, Jar antibody, M6 antibody, MHC95F antibody, MYOVI antibody, Mhc95F antibody, MyoVI antibody, Myosin VI antibody, jag antibody, ms(3)06746 antibody, myosins VI antibody, DFNA22 antibody, DFNB37 antibody, BC029719 antibody, Tlc antibody, sv antibody, RGD1560646 antibody, CMY6 antibody, jaguar antibody, myosin VI antibody, jar antibody, LOC373230 antibody, MYO6 antibody, myo6 antibody, Myo6 antibody
    Background

    Synonyms: Deafness autosomal recessive 37, DFNA 22, DFNA22, DFNB 37, DFNB37, KIAA0389, MYO 6, Myo6, MYO6_HUMAN, Myosin 6, Myosin VI, Myosin-VI, Myosin6, MyosinVI, Unconventional myosin-6.

    Background: Myosin VI a molecular motor involved in intracellular vesicle and organelle transport, is the only Myosin motor that binds to the pointed end of Actin. This unique Myosin has only one light chain in the lever-arm domain and has highly irregular stepping with a wide range of step sizes, unlike that of other characterized Myosins. It associates with Clathrin-coated vesicles and disabled 2, indicating a role for Myosin VI in endocytosis. Mouse Myosin VI is expressed within the sensory hair cells of the cochlea. Human Myosin VI is mapped to the centromeric region of chromosome 6, a region that shows syntenic homology with the corresponding mouse chromosome 9 region, where the Snell?s Waltzer mutation is located. The behavioral effects of the mouse Snell?s Waltzer mutation are lack of responsiveness to sound, hyperactivity, head tossing and circling, due to the disorganization and fusing of stereocilia bundles within the inner ear. Defects of Myosin VI cause autosomal dominant nonsyndromic sensori-neural deafness in humans. Human Myosin VI is expressed in fetal cochlea and brain, as well as in adult brain.

    Pathways
    Sensory Perception of Sound, Dicarboxylic Acid Transport, Asymmetric Protein Localization
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