RASSF5 antibody (AA 321-418)

Catalog No. ABIN1386228

Product Details anti-RASSF5 Antibody

Target: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Binding Specificity: AA 321-418

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASSF5 antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RASSF5

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-RASSF5 antibody (ABIN1386228)

Yang, Kong, Jin, Hergovich, Püschel: "Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway." in: Journal of cell science, Vol. 127, Issue Pt 16, pp. 3463-76, (2014) (PubMed).

Target Details for RASSF5

Target: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Alternative Name: RASSF5 (RASSF5 Products)

Synonyms: Maxp1 antibody, NORE1 antibody, NORE1A antibody, NORE1B antibody, RAPL antibody, RASSF3 antibody, 1300019G20Rik antibody, AU042887 antibody, Nore1 antibody, Nore1A antibody, Nore1B antibody, Rapl antibody, Ras association domain family member 5 antibody, Ras association (RalGDS/AF-6) domain family member 5 antibody, RASSF5 antibody, Rassf5 antibody

Background:

Synonyms: RAPL, Maxp1, NORE1, NORE1A, NORE1B, RASSF3, Ras association domain-containing protein 5, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RASSF5

Background: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Gene ID: 83593

UniProt: Q8WWW0

Pathways: TCR Signaling