PPFIA1 antibody (AA 141-190)

Catalog No. ABIN1386160

Product Details anti-PPFIA1 Antibody

Target: PPFIA1 (Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1))

Binding Specificity: AA 141-190

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPFIA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Liprin alpha 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PPFIA1

Target: PPFIA1 (Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1))

Alternative Name: Liprin alpha 1/PPFIA1 (PPFIA1 Products)

Synonyms: LIP.1 antibody, LIP1 antibody, LIPRIN antibody, C030014K08Rik antibody, C87158 antibody, PTPRF interacting protein alpha 1 antibody, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 antibody, PPFIA1 antibody, Ppfia1 antibody

Background:

Synonyms: LAR interacting protein 1, LIP 1, LIP.1, LIP1, LIPRIN, MGC26800, PPFIA 1, PPFIA1, Protein tyrosine phosphatase receptor type f polypeptide PTPRF interacting protein liprin alpha 1, Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1, PTPRF interacting protein alpha 1, LIPA1_HUMAN.

Background: Liprins interact with members of the leukocyte common antigen-related (LAR) family of transmembrane protein tyrosine phosphatases, which are implicated in axon guidance and mammary gland development. Liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR phosphatases. Based on sequence similarities and binding characteristics, liprins are subdivided into Alpha and Beta liprins. Both Alpha and Beta liprins homodimerize via their N-terminal, coiled-coil regions. Liprin Alpha1 is a ubiquitously expressed protein that interacts with the tumor suppressor ING4 to regulate cell migration and possibly prevent metastasis. The interaction between LAR and Liprin Alpha1 can be weakened by treatment of Liprin ? with calf intestinal phosphatase.