DUOX1 antibody (AA 1-100)

Catalog No. ABIN1386159

Product Details anti-DUOX1 Antibody

Target: DUOX1 (Dual Oxidase 1 (DUOX1))

Binding Specificity: AA 1-100

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUOX1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DUOX1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-DUOX1 antibody (ABIN1386159)

Wakatsuki, Furuno, Ohshima, Araki: "Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration." in: The Journal of cell biology, Vol. 211, Issue 4, pp. 881-96, (2015) (PubMed).

Target Details for DUOX1

Target: DUOX1 (Dual Oxidase 1 (DUOX1))

Alternative Name: DUOX1 (DUOX1 Products)

Synonyms: Udx1 antibody, duox1 antibody, LNOX1 antibody, NOXEF1 antibody, THOX1 antibody, 9930101G15Rik antibody, AW987690 antibody, Duox2 antibody, LNOX2 antibody, NOXEF2 antibody, P138-TOX antibody, THOX2 antibody, dual oxidase 1 antibody, dual oxidase antibody, duox1 antibody, DUOX1 antibody, duox antibody, LOC5569378 antibody, Duox1 antibody

Background:

Synonyms: Dual oxidase 1, Dual oxidase 1 precursor, DUOX1, EC 1.11.1, EC 1.6.3.1, Flavoprotein NADPH oxidase, Large NOX 1, LNOX1, Long NOX 1, MGC138840, MGC138841, NADPH thyroid oxidase 1, Nicotinamide adenine dinucleotide phosphate oxidase, NOXEF1, THOX1, Thyroid oxidase 1, DUOX1_HUMAN.

Background: Dual oxidase 1 (DUOX1), a homolog of glycoprotein p91Phox, is expressed in airway epithelium and generates reactive oxygen species (ROS). DUOX1 is a multi-pass membrane protein predominantly expressed in thyrocytes and tracheal surface epithelial cells, as well as thyroid, trachea and bronchium. DUOX1 generates hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. It is also involved in thyroid hormone synthesis and lactoperoxidase-mediated antimicrobial defense in mucosa. DUOX1, which also plays a role in mucin expression, is widely expressed in fetal tissues.

Gene ID: 53905