Girdin antibody (pSer1417)
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- Target See all Girdin (CCDC88A) Antibodies
- Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))
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Binding Specificity
- pSer1417
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Girdin antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Flow Cytometry (FACS)
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat,Dog,Cow,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human Girdin around the phosphorylation site of Ser1417
- Isotype
- IgG
- Top Product
- Discover our top product CCDC88A Primary Antibody
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))
- Alternative Name
- Girdin (CCDC88A Products)
- Background
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Synonyms: APE, GIV, GRDN, HkRP1, GIRDIN, KIAA1212, Akt phosphorylation enhancer, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, Girders of actin filament, Hook-related protein 1, CCDC88A
Background: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
- Gene ID
- 55704
- UniProt
- Q3V6T2
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