SRCAP antibody (AA 665-780)

Catalog No. ABIN1386056

Product Details anti-SRCAP Antibody

Target: SRCAP (Snf2-Related CREBBP Activator Protein (SRCAP))

Binding Specificity: AA 665-780

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRCAP antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SRCAP

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SRCAP

Target: SRCAP (Snf2-Related CREBBP Activator Protein (SRCAP))

Alternative Name: SRCAP (SRCAP Products)

Synonyms: DOMO1 antibody, EAF1 antibody, FLHS antibody, SWR1 antibody, B930091H02Rik antibody, D030022P06Rik antibody, F630004O05Rik antibody, RGD1565642 antibody, Snf2 related CREBBP activator protein antibody, Snf2-related CREBBP activator protein antibody, SRCAP antibody, Srcap antibody

Background:

Synonyms: DOMO1, EAF1, Helicase SRCAP, Snf2 related CBP activator protein, SWR1, SRCAP_HUMAN.

Background: SRCAP (Snf2-related CREBBP activator protein), also known as EAF1, SWR1, or DOMO1, is a 3,230 amino acid protein that belongs to a family of helicases and contains one HSA domain, one helicase C-terminal domain, one helicase ATP-binding domain and three A.T hook DNA-binding domains. Localized to the nucleus, SRCAP functions as a catalytic component of the SRCAP complex, a multi-protein structure that mediates the ATP-dependent exchange of histone dimers for nucleosomal histones, an event that regulates the transcription of select genes via chromatin remodeling. Additionally, the SRCAP complex acts as a coactivator for steroid receptor-mediated transcription, Notch-mediated transcription and CREB-mediated transcription. SRCAP is expressed as multiple alternatively spliced isoforms and is subject to DNA damage-dependent phosphorylation by ATM or ATR.