TNRC6B antibody (AA 25-70)

Catalog No. ABIN1385992

Product Details anti-TNRC6B Antibody

Target: TNRC6B (Trinucleotide Repeat Containing 6B (TNRC6B))

Binding Specificity: AA 25-70

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNRC6B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TNRC6B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TNRC6B

Target: TNRC6B (Trinucleotide Repeat Containing 6B (TNRC6B))

Alternative Name: TNRC6B (TNRC6B Products)

Synonyms: hm:zeh0114 antibody, im:6968518 antibody, wu:fa01f05 antibody, 2700090M07Rik antibody, A730065C02Rik antibody, AI848765 antibody, D230019K20Rik antibody, Cbl27 antibody, trinucleotide repeat containing 6b antibody, trinucleotide repeat containing 6B antibody, trinucleotide repeat containing 6B S homeolog antibody, tnrc6b antibody, TNRC6B antibody, tnrc6b.S antibody, Tnrc6b antibody

Background:

Synonyms: KIAA1093, TNRC 6B, Trinucleotide repeat containing 6B, Trinucleotide repeat containing gene 6B protein, TNR6B_HUMAN.

Background: TNRC6B is a 1,723 amino acid protein that exists as two alternatively spliced isoforms and is thought to be involved in mRNA cleavage events. Expressed ubiquitously, TNRC6B contains one glycine/tryptophan (GW)-rich N-terminal domain, one central glutamine-rich region and one C-terminal RNA recognition motif and is encoded by a gene that maps to human chromosome 22. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulatory RNA Pathways, EGFR Signaling Pathway