GPS1 antibody (AA 324-370)

Catalog No. ABIN1385980

Product Details anti-GPS1 Antibody

Target: GPS1 (G Protein Pathway Suppressor 1 (GPS1))

Binding Specificity: AA 324-370

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CSN1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for GPS1

Target: GPS1 (G Protein Pathway Suppressor 1 (GPS1))

Alternative Name: CSN1 (GPS1 Products)

Synonyms: COPS1 antibody, CSN1 antibody, Cops1 antibody, Csn1 antibody, R75577 antibody, Sgn1 antibody, im:6909260 antibody, im:7145572 antibody, zgc:154082 antibody, csn1 antibody, ARABIDOPSIS THALIANA FUSCA 6 antibody, ATFUS6 antibody, ATSK31 antibody, CONSTITUTIVE PHOTOMORPHOGENIC 11 antibody, COP11 antibody, COP9 SIGNALOSOME SUBUNIT 1 antibody, EMB78 antibody, EMBRYO DEFECTIVE 78 antibody, FUSCA 6 antibody, SHAGGY-LIKE KINASE 31 antibody, SK31 antibody, G protein pathway suppressor 1 antibody, casein alpha s1 antibody, G protein pathway suppressor 1 L homeolog antibody, COP9 signalosome complex subunit 1 antibody, GPS1 antibody, CSN1S1 antibody, LOC693104 antibody, CC1G_07518 antibody, Bm1_55055 antibody, Gps1 antibody, gps1 antibody, gps1.L antibody, FUS6 antibody, csn-1 antibody

Background:

Synonyms: CSN1, COPS1, COP9 signalosome complex subunit 1, SGN1, Signalosome subunit 1, G protein pathway suppressor 1, GPS-1, JAB1-containing signalosome subunit 1, Protein MFH, GPS1

Background: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Gene ID: 2873

UniProt: Q13098

Pathways: Cell Division Cycle