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CHN1 antibody (AA 151-250)

ARHGAP2 Reactivity: Human WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1385870
  • Target See all CHN1 (ARHGAP2) Antibodies
    CHN1 (ARHGAP2) (rho GTPase Activating Protein 2 (ARHGAP2))
    Binding Specificity
    • 14
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 151-250
    Reactivity
    • 34
    • 9
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Host
    • 25
    • 9
    Rabbit
    Clonality
    • 27
    • 7
    Polyclonal
    Conjugate
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    This CHN1 antibody is un-conjugated
    Application
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Alpha-chimerin
    Isotype
    IgG
    Top Product
    Discover our top product ARHGAP2 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    CHN1 (ARHGAP2) (rho GTPase Activating Protein 2 (ARHGAP2))
    Alternative Name
    CHN 1/Alpha-chimerin (ARHGAP2 Products)
    Synonyms
    ARHGAP2 antibody, CHN antibody, DURS2 antibody, NC antibody, RHOGAP2 antibody, 0610007I19Rik antibody, 0710001E19Rik antibody, 1700112L09Rik antibody, 2900046J01Rik antibody, AI413815 antibody, chimaerin antibody, wu:fr89a09 antibody, zgc:56160 antibody, zgc:92906 antibody, N-chimaerin antibody, chimerin 1 antibody, chimerin 1 L homeolog antibody, CHN1 antibody, Chn1 antibody, chn1.L antibody, chn1 antibody
    Background

    Synonyms: A-chimaerin, Alpha-chimerin, ARHGAP2, CHIN_HUMAN, CHN, Chn1, N chimaerin, N chimerin, N-chimaerin, N-chimerin, NC, Rho GTPase-activating protein 2, RHOGAP2.

    Background: The Rac-GAP chimaerin family member Alpha-chimaerin (also known as N-chimaerin or rho GTPase-activating protein 2) has two splice variants: Alpha1 and Alpha2. The ?-chimaerin variant is a neuron-specific, diacylglycerol-binding and GTPase-activating protein for ras-related protein Rac 1. This variant lacks the N-terminal SH2 domain that is present in the Alpha2 variant. By inactivating Rac 1, Alpha1-chimaerin plays a significant role in the regulation of dendritic growth during neuronal development. It is recruited to the plasma membrane by phospholipase C Beta-coupled cell surface receptors activating the downstream generation of DAG (diacylglycerol). Overexpression of Alpha1-chimaerin results in dendritic spine retraction and the loss of dendritic branches. In the presence of reduced neuronal activity, Alpha1-chimaerin expression is down-regulated resulting in an increase in spine growth and dendritic branching.

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