DIS3L antibody

Catalog No. ABIN1385653

Product Details anti-DIS3L Antibody

Target: DIS3L (DIS3-Like Exonuclease 1 (DIS3L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIS3L antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DIS3L

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for DIS3L

Target: DIS3L (DIS3-Like Exonuclease 1 (DIS3L))

Alternative Name: DIS3L (DIS3L Products)

Synonyms: DIS3L1 antibody, AV340375 antibody, RGD1308959 antibody, zgc:158615 antibody, DIS3 like exosome 3'-5' exoribonuclease antibody, DIS3-like exosome 3'-5' exoribonuclease antibody, DIS3L antibody, dis3l antibody, Dis3l antibody, dis3l.L antibody

Background:

Synonyms: DIS3 like exonuclease 1, DIS3 mitotic control homolog S. cerevisiae like, FLJ38088, KIAA1955, MGC4562, DI3L1_HUMAN.

Background: The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3? regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events.

Gene ID: 115752