CPN2 antibody

Catalog No. ABIN1385520

Product Details anti-CPN2 Antibody

Target: CPN2 (Carboxypeptidase N Subunit 2 (CPN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPN2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CPN2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CPN2

Target: CPN2 (Carboxypeptidase N Subunit 2 (CPN2))

Alternative Name: CPN2 (CPN2 Products)

Synonyms: cpn2 antibody, im:7138819 antibody, Cpn2 antibody, GB13055 antibody, DKFZp470I1612 antibody, ACBP antibody, 1300018K11Rik antibody, RGD1305170 antibody, carboxypeptidase N subunit 2 antibody, zgc:153913 antibody, carboxypeptidase N, polypeptide 2 antibody, CPN2 antibody, zgc:153913 antibody, Cpn2 antibody, CpipJ_CPIJ008561 antibody, CpipJ_CPIJ010495 antibody, CpipJ_CPIJ013628 antibody

Background:

Synonyms: CPN 2, CPN2, CPN-2, ACBP, Carboxypeptidase N 83 kDa chain, Carboxypeptidase N large subunit, Carboxypeptidase N regulatory subunit, Carboxypeptidase N subunit 2 [Precursor], carboxypeptidase N, polypeptide 2, CPN2_HUMAN.

Background: CPN2 is a zinc metalloprotease, and cleaves carboxy-terminal arginines and lysines from peptides found in the bloodstream such as complement anaphylatoxins, kinins, and creatine kinase MM (CK-MM). By removing only one amino acid, CPN has the ability to change peptide activity and receptor binding. It is a 280 kDa tetrameric glycoprotein that is synthesized by the liver and secreted into the plasma. It consists of 2 identical 83 kDa regulatory subunits (CPN2) and 2 identical 50 kDa catalytic subunits (CPN1). CPN2, the 83 kDa subunit, binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit. CPN is a member of a larger family of carboxypeptidases, many of which also cleave arginine and lysine. Because of the highly conserved active sites and the possible redundant functions of carboxypeptidases, it has been difficult to elucidate the role of CPN in disease processes.

Gene ID: 1370