PGBD3 antibody (AA 410-460)

Catalog No. ABIN1385394

Product Details anti-PGBD3 Antibody

Target: PGBD3 (PiggyBac Transposable Element Derived 3 (PGBD3))

Binding Specificity: AA 410-460

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PGBD3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PGBD3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PGBD3

Target: PGBD3 (PiggyBac Transposable Element Derived 3 (PGBD3))

Alternative Name: PGBD3 (PGBD3 Products)

Synonyms: PGBD3 antibody, piggyBac transposable element derived 3 antibody, ERCC excision repair 6, chromatin remodeling factor antibody, PGBD3 antibody, ERCC6 antibody

Background:

Synonyms: PGBD 3, PiggyBac transposable element derived 3, PiggyBac transposable element derived protein 3, PGBD3_HUMAN.

Background: PiggyBac transposable element derived 3, also known as PGBD3, encodes a 593 amino acid transposase and is a member of the piggyBac transposable element derived (PGBD) gene family, which includes several genes that are derived from piggyBac transposons. Initially characterized in the cabbacge looper moth, Trichoplusia ni, the PGBD family is conserved in a wide variety of species, including protozoa and primates. More specifically, while PGBD3 and PGBD4 are primate-specific genes, the other three members of the PGBD family (namely PGBD1, PGBD2 and PGBD5) are conserved among a variety of vertebrates. PGBD3 appears to be novel, with no clear relationship to other transposases or other known protein families. However, the PGBD3 gene overlaps with the CSB gene on chromosome 10 and, with the CSB gene, plays a role in Cockayne syndrome, a rare disorder characterized by premature aging, microcephaly, photosensitivity and severe neurologic degeneration.

Gene ID: 267004

UniProt: Q8N328

Pathways: Chromatin Binding