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FBXW12 antibody

FBXW12 Reactivity: Human WB, IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1385341
  • Target See all FBXW12 Antibodies
    FBXW12 (F-Box and WD Repeat Domain Containing 12 (FBXW12))
    Reactivity
    Human
    Host
    • 36
    • 2
    Rabbit
    Clonality
    • 35
    • 2
    Polyclonal
    Conjugate
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FBXW12 antibody is un-conjugated
    Application
    • 33
    • 20
    • 16
    • 14
    • 12
    • 5
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FBXW12/FBXO35
    Isotype
    IgG
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  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    FBXW12 (F-Box and WD Repeat Domain Containing 12 (FBXW12))
    Alternative Name
    FBXW12 (FBXW12 Products)
    Synonyms
    FBW12 antibody, FBXO12 antibody, FBXO35 antibody, RGD1307859 antibody, F-box and WD repeat domain containing 12 antibody, FBXW12 antibody, Fbxw12 antibody
    Background

    Synonyms: F box and WD 40 domain containing protein 12; F box and WD 40 domain protein 12; F box and WD repeat domain containing 12; F box and WD40 repeat containing protein; F box only protein 35; F box/WD repeat containing protein 12; F-box and WD-40 domain-containing protein 12; F-box only protein 35; F-box/WD repeat-containing protein 12; Fbw12; FBW12_HUMAN; FBX12; FBXO12; FBXO35; FBXW 12; FBXW12.

    Background: Belonging to the F-box family of proteins, FBXO35 (F-box only protein 35), also designated F-box and WD-40 domain-containing protein 12 (FBXW12 or FBXO12), is a 464 amino acid protein that contains one C-terminal F-box domain. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein)-type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular mechanisms, including the cell cycle, the immune response, signaling cascades and developmental processes. They function by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and -catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO35 can directly interact with Skp1 p19 and CUL-1. FBXO35 is ubiquitously expressed at low levels in most human tissues.

    Gene ID
    285231
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