CECR1 antibody (AA 450-500)
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- Target See all CECR1 Antibodies
- CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1))
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Binding Specificity
- AA 450-500
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CECR1 antibody is un-conjugated
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human CECR1/ADGF
- Isotype
- IgG
- Top Product
- Discover our top product CECR1 Primary Antibody
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- Application Notes
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FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1))
- Alternative Name
- CECR1 (CECR1 Products)
- Synonyms
- cecr1 antibody, fj65e02 antibody, wu:fj65e02 antibody, CECR1 antibody, ADA2 antibody, ADGF antibody, IDGFL antibody, adenosine deaminase 2a antibody, cat eye syndrome chromosome region, candidate 1 antibody, adenosine deaminase 2 antibody, adenosine deaminase 2 L homeolog antibody, ada2a antibody, CECR1 antibody, ADA2 antibody, ada2.L antibody
- Background
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Synonyms: ADGF, Cat eye syndrome chromosome region candidate 1, Cat eye syndrome critical region protein 1, Cat eye syndrome critical region protein 1 precursor, CECR 1, IDGFL, CECR1_HUMAN.
Background: CECR1 is a member of the adenosine and AMP deaminases family. It may act as a growth factor and have adenosine deaminase activity. It is a candidate gene for cat eye syndrome. Two transcript variants encoding distinct isoforms have been identified for this gene.Adenosine deaminase is an enzyme that is present in most tissues and exists predominantly as a monomer, although in some tissues it is associated with adenosine deaminase-binding protein. Adenosine deaminase degrades extracellular adenosine, which is toxic for lymphocytes. A novel family of growth factors that share sequence similarity to adenosine deaminase has been identified. The cat eye syndrome critical region protein (CECR) family includes CECR1, CECR2, CECR3, CECR4, CECR5, CECR6, CECR7, CECR8 and CECR9. The genes encoding CECR proteins are candidates for Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. CES is characterized by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development. CECR family members are widely expressed. Specifically, CECR1 has the highest expression in adult heart, lung, lymphoblasts and placenta. CECR2 is also involved in neurulation and chromatin remodeling. Mutations in the CECR2 gene result in neural tube defects.
- Gene ID
- 51816
- UniProt
- Q9NZK5
- Pathways
- Ribonucleoside Biosynthetic Process
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