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CECR1 antibody (AA 450-500)

CECR1 Reactivity: Human IHC (p), FACS, IF (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1385331
  • Target See all CECR1 Antibodies
    CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1))
    Binding Specificity
    • 4
    • 1
    • 1
    • 1
    • 1
    AA 450-500
    Reactivity
    • 19
    • 1
    Human
    Host
    • 16
    • 4
    Rabbit
    Clonality
    • 18
    • 2
    Polyclonal
    Conjugate
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CECR1 antibody is un-conjugated
    Application
    • 12
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CECR1/ADGF
    Isotype
    IgG
    Top Product
    Discover our top product CECR1 Primary Antibody
  • Application Notes
    FCM 1:20-100
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1))
    Alternative Name
    CECR1 (CECR1 Products)
    Synonyms
    cecr1 antibody, fj65e02 antibody, wu:fj65e02 antibody, CECR1 antibody, ADA2 antibody, ADGF antibody, IDGFL antibody, adenosine deaminase 2a antibody, cat eye syndrome chromosome region, candidate 1 antibody, adenosine deaminase 2 antibody, adenosine deaminase 2 L homeolog antibody, ada2a antibody, CECR1 antibody, ADA2 antibody, ada2.L antibody
    Background

    Synonyms: ADGF, Cat eye syndrome chromosome region candidate 1, Cat eye syndrome critical region protein 1, Cat eye syndrome critical region protein 1 precursor, CECR 1, IDGFL, CECR1_HUMAN.

    Background: CECR1 is a member of the adenosine and AMP deaminases family. It may act as a growth factor and have adenosine deaminase activity. It is a candidate gene for cat eye syndrome. Two transcript variants encoding distinct isoforms have been identified for this gene.Adenosine deaminase is an enzyme that is present in most tissues and exists predominantly as a monomer, although in some tissues it is associated with adenosine deaminase-binding protein. Adenosine deaminase degrades extracellular adenosine, which is toxic for lymphocytes. A novel family of growth factors that share sequence similarity to adenosine deaminase has been identified. The cat eye syndrome critical region protein (CECR) family includes CECR1, CECR2, CECR3, CECR4, CECR5, CECR6, CECR7, CECR8 and CECR9. The genes encoding CECR proteins are candidates for Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. CES is characterized by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development. CECR family members are widely expressed. Specifically, CECR1 has the highest expression in adult heart, lung, lymphoblasts and placenta. CECR2 is also involved in neurulation and chromatin remodeling. Mutations in the CECR2 gene result in neural tube defects.

    Gene ID
    51816
    UniProt
    Q9NZK5
    Pathways
    Ribonucleoside Biosynthetic Process
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