IL12 antibody

Catalog No. ABIN1383952

Product Details anti-IL12 Antibody

Target: IL12 (Interleukin 12 (IL12))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL12 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), ELISpot

Specificity: Recognises both natural and recombinant p40 subunit alone and in its IL-12 form (associated with p35) and in its IL-23 form (associated with p19)

Purification: Ion exchange chromatography

Sterility: 0.22 μm filtered

Immunogen: Recombinant human IL-12,Myeloma X63/AG.8653 x Balb/c spleen cells

Clone: B-P24

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

References for anti-IL12 antibody (ABIN1383952)

Nagai, Devergne, Mueller, Perkins, van Seventer, van Seventer: "Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation" in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 10, pp. 5233-43, (2003) (PubMed).

Target Details for IL12

Target: IL12 (Interleukin 12 (IL12))

Alternative Name: IL-12p40+p70 (IL12 Products)

Background: IL-12/IL23p40, IL-12p70

Pathways: JAK-STAT Signaling, TLR Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome