CD130/gp130 antibody

Catalog No. ABIN1383678

Product Details anti-CD130/gp130 Antibody

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD130/gp130 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Functional Studies (Func)

Specificity: Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein

Purification: Ion exchange chromatography

Sterility: 0.22 μm filtered

Immunogen: Natural soluble gp130,Myeloma X63/AG.8653 x Balb/c spleen cells

Clone: B-R3

Isotype: IgG2a, kappa

Biological Activity Comment: Inhibits IL-6, IL-11, CNTF, LIF and OSM activities

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

References for anti-CD130/gp130 antibody (ABIN1383678)

Chautard, Loubeau, Tchirkov, Chassagne, Vermot-Desroches, Morel, Verrelle: "Akt signaling pathway: a target for radiosensitizing human malignant glioma." in: Neuro-oncology, Vol. 12, Issue 5, pp. 434-43, (2010) (PubMed).

Waetzig, Chalaris, Rosenstiel, Suthaus, Holland, Karl, Vallés Uriarte, Till, Scheller, Grötzinger, Schreiber, Rose-John, Seegert: "N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130." in: The Journal of biological chemistry, Vol. 285, Issue 3, pp. 1781-9, (2010) (PubMed).

Memoli, Grandaliano, Soccio, Postiglione, Guida, Bisesti, Esposito, Procino, Marrone, Michael, Andreucci, Schena, Pertosa: "In vivo modulation of soluble \" IL-6 receptor synthesis and release in ESRD." in: Journal of the American Society of Nephrology : JASN, Vol. 16, Issue 4, pp. 1099-107, (2005) (PubMed).

Duplomb, Chaigne-Delalande, Vusio, Raher, Jacques, Godard, Blanchard: "Soluble mannose 6-phosphate/insulin-like growth factor II (IGF-II) receptor inhibits interleukin-6-type cytokine-dependent proliferation by neutralization of IGF-II." in: Endocrinology, Vol. 144, Issue 12, pp. 5381-9, (2003) (PubMed).

Jover, Bort, Gómez-Lechón, Castell: "Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 13, pp. 1799-801, (2002) (PubMed).

Burger, Guenther, Bakker, Schmalzing, Bernand, Baum, Duerr, Hocke, Steininger, Gebhart, Gramatzki: "Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma." in: The hematology journal : the official journal of the European Haematology Association / EHA, Vol. 2, Issue 1, pp. 42-53, (2002) (PubMed).

Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." in: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).

Aoki, Narazaki, Kishimoto, Tosato: "Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus." in: Blood, Vol. 98, Issue 10, pp. 3042-9, (2001) (PubMed).

Olivier, Auguste, Chabbert, Lelièvre, Chevalier, Gascan: "Identification of a gp130 cytokine receptor critical site involved in oncostatin M response." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5648-56, (2000) (PubMed).

Gu, De Vos, Rebouissou, Jourdan, Zhang, Rossi, Wijdenes, Klein: "Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors." in: Leukemia, Vol. 14, Issue 1, pp. 188-97, (2000) (PubMed).

Müller-Newen, Küster, Wijdenes, Schaper, Heinrich: "Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies." in: The Journal of biological chemistry, Vol. 275, Issue 7, pp. 4579-86, (2000) (PubMed).

Blanchard, Duplomb, Raher, Vusio, Hoflack, Jacques, Godard: "Mannose 6-Phosphate/Insulin-like growth factor II receptor mediates internalization and degradation of leukemia inhibitory factor but not signal transduction." in: The Journal of biological chemistry, Vol. 274, Issue 35, pp. 24685-93, (1999) (PubMed).

Thiel, Behrmann, Dittrich, Muys, Tavernier, Wijdenes, Heinrich, Graeve: "Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway." in: The Biochemical journal, Vol. 330 ( Pt 1), pp. 47-54, (1998) (PubMed).

Lebeau, Montero Julian, Wijdenes, Müller-Newen, Dahmen, Chérel, Heinrich, Brailly, Hallet, Godard, Minvielle, Jacques: "Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties." in: FEBS letters, Vol. 407, Issue 2, pp. 141-7, (1997) (PubMed).

Auguste, Guillet, Fourcin, Olivier, Veziers, Pouplard-Barthelaix, Gascan: "Signaling of type II oncostatin M receptor." in: The Journal of biological chemistry, Vol. 272, Issue 25, pp. 15760-4, (1997) (PubMed).

Gu, Wijdenes, Zhang, Hallet, Clement, Klein: "Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M." in: Journal of immunological methods, Vol. 190, Issue 1, pp. 21-7, (1996) (PubMed).

Chevalier, Fourcin, Robledo, Wijdenes, Pouplard-Barthelaix, Gascan: "Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein." in: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14764-72, (1996) (PubMed).

Gu, Costes, Lu, Zhang, Pitard, Moreau, Bataille, Wijdenes, Rossi, Klein: "Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop." in: Blood, Vol. 88, Issue 10, pp. 3972-86, (1996) (PubMed).

Target Details for CD130/gp130

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Alternative Name: CD130 (IL6ST Products)

Synonyms: CD130 antibody, CDW130 antibody, GP130 antibody, IL-6RB antibody, 5133400A03Rik antibody, AA389424 antibody, BB405851 antibody, D13Ertd699e antibody, gp130 antibody, Ac1055 antibody, Gp130 antibody, Il-6rb antibody, IL-6 antibody, interleukin 6 signal transducer antibody, IL6ST antibody, Il6st antibody, il6st antibody

Background: Gp130

Molecular Weight: 130-140 kDa

Pathways: JAK-STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints