IL-6 Receptor antibody

Catalog No. ABIN1383672

Product Details anti-IL-6 Receptor Antibody

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-6 Receptor antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA, Flow Cytometry (FACS), Functional Studies (Func)

Specificity: Recognises the Interleukin-6 Ra subunit, IL-6 Ra, IL-6 R, a 80 kDa protein

Purification: Ion exchange chromatography

Sterility: 0.22 μm filtered

Immunogen: gp80 transfected CHO cell line,Myeloma X63/AG.8653 x Balb/c spleen cells

Clone: B-R6

Isotype: IgG1 kappa

Biological Activity Comment: Inhibits IL-6 induced proliferation of XG-1 cells

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

References for anti-IL-6 Receptor antibody (ABIN1383672)

Burger, Guenther, Bakker, Schmalzing, Bernand, Baum, Duerr, Hocke, Steininger, Gebhart, Gramatzki: "Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma." in: The hematology journal : the official journal of the European Haematology Association / EHA, Vol. 2, Issue 1, pp. 42-53, (2002) (PubMed).

Menetrier-Caux, Thomachot, Alberti, Montmain, Blay: "IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells." in: Cancer research, Vol. 61, Issue 7, pp. 3096-104, (2001) (PubMed).

Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." in: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).

Gu, De Vos, Rebouissou, Jourdan, Zhang, Rossi, Wijdenes, Klein: "Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors." in: Leukemia, Vol. 14, Issue 1, pp. 188-97, (2000) (PubMed).

Menetrier-Caux, Montmain, Dieu, Bain, Favrot, Caux, Blay: "Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor." in: Blood, Vol. 92, Issue 12, pp. 4778-91, (1999) (PubMed).

Dubois, Barthélémy, Durand, Liu, Caux, Brière: "Toward a role of dendritic cells in the germinal center reaction: triggering of B cell proliferation and isotype switching." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 6, pp. 3428-36, (1999) (PubMed).

Dubois, Massacrier, Vanbervliet, Fayette, Brière, Banchereau, Caux: "Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 5, pp. 2223-31, (1998) (PubMed).

Larregina, Morelli, Kolkowski, Sanjuan, Barboza, Fainboim: "Pattern of cytokine receptors expressed by human dendritic cells migrated from dermal explants." in: Immunology, Vol. 91, Issue 2, pp. 303-13, (1997) (PubMed).

Müller-Newen, Köhne, Keul, Hemmann, Müller-Esterl, Wijdenes, Brakenhoff, Hart, Heinrich: "Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing." in: European journal of biochemistry / FEBS, Vol. 236, Issue 3, pp. 837-42, (1996) (PubMed).

Target Details for IL-6 Receptor

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Alternative Name: CD126 (IL6R Products)

Synonyms: IL6R antibody, il-6ra antibody, CD126 antibody, IL-6R-1 antibody, IL-6RA antibody, IL6Q antibody, IL6RA antibody, IL6RQ antibody, gp80 antibody, IL6R1 antibody, Il6ra antibody, IL-6Ralpha antibody, IL-6R antibody, Il6r antibody, interleukin 6 receptor antibody, interleukin 6 receptor, alpha antibody, IL6R antibody, il6r antibody, Il6r antibody, Il6ra antibody

Background: IL-6R / gp80

Molecular Weight: 80 kDa

Pathways: JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints